3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr(−/−) mice

AIMS: Atherosclerosis is a chronic inflammatory disease involving immunological and metabolic processes. Metabolism of tryptophan (Trp) via the kynurenine pathway has shown immunomodulatory properties and the ability to modulate atherosclerosis. We identified 3-hydroxyanthranilic acid (3-HAA) as a k...

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Detalles Bibliográficos
Autores principales: Berg, Martin, Polyzos, Konstantinos A, Agardh, Hanna, Baumgartner, Roland, Forteza, Maria J, Kareinen, Ilona, Gisterå, Anton, Bottcher, Gerhard, Hurt-Camejo, Eva, Hansson, Göran K, Ketelhuth, Daniel F J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519886/
https://www.ncbi.nlm.nih.gov/pubmed/31589306
http://dx.doi.org/10.1093/cvr/cvz258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519886/
https://www.ncbi.nlm.nih.gov/pubmed/31589306
http://dx.doi.org/10.1093/cvr/cvz258

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