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Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis

AIMS: Cardiovascular side effects caused by non-steroidal anti-inflammatory drugs (NSAIDs), which all inhibit cyclooxygenase (COX)-2, have prevented development of new drugs that target prostaglandins to treat inflammation and cancer. Microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors have e...

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Detalles Bibliográficos
Autores principales:	Kirkby, Nicholas S, Raouf, Joan, Ahmetaj-Shala, Blerina, Liu, Bin, Mazi, Sarah I, Edin, Matthew L, Chambers, Mark Geoffrey, Korotkova, Marina, Wang, Xiaomeng, Wahli, Walter, Zeldin, Darryl C, Nüsing, Rolf, Zhou, Yingbi, Jakobsson, Per-Johan, Mitchell, Jane A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519887/ https://www.ncbi.nlm.nih.gov/pubmed/31688905 http://dx.doi.org/10.1093/cvr/cvz290

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