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The hybrid models, containing hydrolytic and electron-driven processes, in theoretical study of oxaliplatin biotransformation

The results of theoretical simulations of reaction paths for oxaliplatin from pro-drug into its active form responsible for cytostatic effect are presented. The studies based on the quantum-chemical density functional theory approach were performed considering environmental influence resulting from...

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Detalles Bibliográficos
Autores principales: Kuduk-Jaworska, Janina, Jański, Jerzy J., Roszak, Szczepan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519906/
https://www.ncbi.nlm.nih.gov/pubmed/32979094
http://dx.doi.org/10.1007/s00894-020-04549-4