Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C

BRCA2 is crucial for repairing DNA double-strand breaks with high fidelity, and loss of BRCA2 increases the risks of developing breast and ovarian cancers. Herein, we show that BRCA2 is inactively mutated in 10% of gastric and 7% of colorectal adenocarcinomas, and that this inactivation is significa...

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Detalles Bibliográficos
Autores principales: Chen, Xiaomin, Peng, Fangfei, Ji, Yan, Xiang, Honggang, Wang, Xiang, Liu, Tingting, Wang, Heng, Han, Yumin, Wang, Changxu, Zhang, Yongfeng, Kong, Xiangyin, Lang, Jing-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519908/
https://www.ncbi.nlm.nih.gov/pubmed/32980867
http://dx.doi.org/10.1038/s41419-020-03013-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519908/
https://www.ncbi.nlm.nih.gov/pubmed/32980867
http://dx.doi.org/10.1038/s41419-020-03013-8

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