A genome‐scale CRISPR knock‐out screen in chronic myeloid leukemia identifies novel drug resistance mechanisms along with intrinsic apoptosis and MAPK signaling

Understanding resistance mechanisms in cancer is of utmost importance for the discovery of novel “druggable” targets. Efficient genetic screening, now even more possible with CRISPR‐Cas9 gene‐editing technology, next‐generation sequencing and bioinformatics, is an important tool for deciphering nove...

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Detalles Bibliográficos
Autores principales: Lewis, Matthieu, Prouzet‐Mauléon, Valérie, Lichou, Florence, Richard, Elodie, Iggo, Richard, Turcq, Béatrice, Mahon, François‐Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520295/
http://dx.doi.org/10.1002/cam4.3231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520295/
http://dx.doi.org/10.1002/cam4.3231

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