Hsp90 inhibition and co‐incubation with pertuzumab induce internalization and degradation of trastuzumab: Implications for use of T‐DM1

The receptor tyrosine kinase HER2 is associated with a number of human malignancies and is an important therapeutic target. The antibody‐drug conjugate trastuzumab emtansine (T‐DM1; Kadcyla(®)) is recommended as a first‐line treatment for patients with HER2‐positive metastatic breast cancer. T‐DM1 c...

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Detalles Bibliográficos
Autores principales: Skeie, Marianne, Nikolaysen, Filip, Chitano, Ylenia, Stang, Espen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520337/
https://www.ncbi.nlm.nih.gov/pubmed/32672902
http://dx.doi.org/10.1111/jcmm.15643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520337/
https://www.ncbi.nlm.nih.gov/pubmed/32672902
http://dx.doi.org/10.1111/jcmm.15643

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