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Comparison of covariate selection methods with correlated covariates: prior information versus data information, or a mixture of both?

The inclusion of covariates in population models during drug development is a key step to understanding drug variability and support dosage regimen proposal, but high correlation among covariates often complicates the identification of the true covariate. We compared three covariate selection method...

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Detalles Bibliográficos
Autores principales: Chasseloup, Estelle, Yngman, Gunnar, Karlsson, Mats O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520415/
https://www.ncbi.nlm.nih.gov/pubmed/32661654
http://dx.doi.org/10.1007/s10928-020-09700-5