EGLIF-CAR-T Cells Secreting PD-1 Blocking Antibodies Significantly Mediate the Elimination of Gastric Cancer

OBJECTIVE: To investigate the anti-tumor effects of programmed cell death protein 1 (PD-1) scFv-secreting EGFR-chimeric antigen receptor-modified (CAR)-T cells against gastric cancer. METHODS: Second-generation EGFR-CAR-T cells and fourth-generation PD-1 scFv-secreting EGFR-CAR-T cells were engineer...

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Detalles Bibliográficos
Autores principales: Zhou, Jing-Tao, Liu, Jiang-Hao, Song, Ting-Ting, Ma, Bo, Amidula, Nuermaimait, Bai, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520465/
https://www.ncbi.nlm.nih.gov/pubmed/33061585
http://dx.doi.org/10.2147/CMAR.S260915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520465/
https://www.ncbi.nlm.nih.gov/pubmed/33061585
http://dx.doi.org/10.2147/CMAR.S260915

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