Intratumoral administration of the Toll‐like receptor 7/8 agonist 3M‐052 enhances interferon‐driven tumor immunogenicity and suppresses metastatic spread in preclinical triple‐negative breast cancer

OBJECTIVES: Loss of tumor‐inherent type I interferon (IFN) signalling has been closely linked to accelerated metastatic progression via decreased immunogenicity and antitumor immunity. Previous studies in murine models of triple‐negative breast cancer (TNBC) demonstrate that systemic IFN inducers ar...

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Detalles Bibliográficos
Autores principales: Zanker, Damien J, Spurling, Alex J, Brockwell, Natasha K, Owen, Katie L, Zakhour, Jasmine M, Robinson, Tina, Duivenvoorden, Hendrika M, Hertzog, Paul J, Mullins, Stefanie R, Wilkinson, Robert W, Parker, Belinda S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520806/
https://www.ncbi.nlm.nih.gov/pubmed/33005415
http://dx.doi.org/10.1002/cti2.1177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520806/
https://www.ncbi.nlm.nih.gov/pubmed/33005415
http://dx.doi.org/10.1002/cti2.1177

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