Cargando…

Intratumoral administration of the Toll‐like receptor 7/8 agonist 3M‐052 enhances interferon‐driven tumor immunogenicity and suppresses metastatic spread in preclinical triple‐negative breast cancer

OBJECTIVES: Loss of tumor‐inherent type I interferon (IFN) signalling has been closely linked to accelerated metastatic progression via decreased immunogenicity and antitumor immunity. Previous studies in murine models of triple‐negative breast cancer (TNBC) demonstrate that systemic IFN inducers ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zanker, Damien J, Spurling, Alex J, Brockwell, Natasha K, Owen, Katie L, Zakhour, Jasmine M, Robinson, Tina, Duivenvoorden, Hendrika M, Hertzog, Paul J, Mullins, Stefanie R, Wilkinson, Robert W, Parker, Belinda S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520806/ https://www.ncbi.nlm.nih.gov/pubmed/33005415 http://dx.doi.org/10.1002/cti2.1177

Ejemplares similares

Intratumoral immunotherapy with the TLR7/8 agonist 3M-052
por: Smirnov, DV, et al.
Publicado: (2013)

Tumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC
por: Brockwell, Natasha K., et al.
Publicado: (2019)

Discriminating the earliest stages of mammary carcinoma using myoepithelial and proliferative markers
por: Duivenvoorden, Hendrika M., et al.
Publicado: (2018)

High-content siRNA 3D co-cultures to identify myoepithelial cell-derived breast cancer suppressor proteins
por: Duivenvoorden, Hendrika M., et al.
Publicado: (2021)

Innate and Adaptive Responses of Intratumoral Immunotherapy with Endosomal Toll-Like Receptor Agonists
por: Andón, Fernando Torres, et al.
Publicado: (2022)

Title unknown, CERN-ALEPH-87-052
por: Knobloch, J
Publicado: (1987)

Preclinical evaluation of immunogenicity, efficacy and safety of a recombinant plant-based SARS-CoV-2 RBD vaccine formulated with 3M-052-Alum adjuvant
por: Phoolcharoen, Waranyoo, et al.
Publicado: (2023)

Prostate cancer cell‐intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone
por: Owen, Katie L, et al.
Publicado: (2020)

Preclinical outcomes of Intratumoral Modulation Therapy for glioblastoma
por: Di Sebastiano, Andrea R., et al.
Publicado: (2018)

In silico experiment with an-antigen-toll like receptor-5 agonist fusion construct for immunogenic application to Helicobacter pylori
por: Haghighi, Mohamad Ali, et al.
Publicado: (2013)

The effect of Toll-like receptor agonists on the immunogenicity of MVA-SARS-2-S vaccine after intranasal administration in mice
por: Do, Kim Thi Hoang, et al.
Publicado: (2023)

Toll-Like Receptor 9 Agonists in Cancer
por: Karapetyan, Lilit, et al.
Publicado: (2020)

Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice
por: Shekhar, Tanmay M., et al.
Publicado: (2019)

Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies
por: Mullins, Stefanie R., et al.
Publicado: (2019)

Toll-Like Receptor 4 Expression on Lymphoma Cells Is Critical for Therapeutic Activity of Intratumoral Therapy With Synthetic TLR4 Agonist Glucopyranosyl Lipid A
por: Lu, Hailing, et al.
Publicado: (2020)

Association of HIV diversity and virologic outcomes in early antiretroviral treatment: HPTN 052
por: Palumbo, Philip J., et al.
Publicado: (2017)

P052 Treatment preferences and help seeking behaviours of Australian adults with insomnia symptoms
por: Haycock, J, et al.
Publicado: (2022)

Investigating the Role of Heparanase in Breast Cancer Development Utilising the MMTV-PyMT Murine Model of Mammary Carcinoma
por: Jayatilleke, Krishnath M., et al.
Publicado: (2023)

Preclinical and clinical investigation of intratumoral chemotherapy pharmacokinetics in DIPG using gemcitabine
por: Green, Adam L, et al.
Publicado: (2020)

Surface Immunogenic Protein of Streptococcus Group B is an Agonist of Toll-Like Receptors 2 and 4 and a Potential Immune Adjuvant
por: Diaz-Dinamarca, Diego A., et al.
Publicado: (2020)

Toll like-receptor agonist Pam(3)Cys modulates the immunogenicity of liposomes containing the tuberculosis vaccine candidate H56
por: Kennerknecht, Kathrin, et al.
Publicado: (2020)

Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma
por: Boudreau, C. Elizabeth, et al.
Publicado: (2021)

SAT-LB052 Intravenous Bisphosphonate Therapy in Children with Spinal Muscular Atrophy
por: Nasomyont, Nat, et al.
Publicado: (2019)

SUN-052 Low Vitamin D Is Associated with Coronary Atherosclerosis in Women with HIV
por: Cheru, Lediya, et al.
Publicado: (2019)

Identification of Loliolide with Anti-Aging Properties from Scenedesmus deserticola JD052
por: Cho, Dae-Hyun, et al.
Publicado: (2023)

P052 Is Circadian Adaptation to Night Work Affected by the Intensity of Ambient Lighting?
por: Roach, G, et al.
Publicado: (2023)

Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses
por: Jiang, Xiaodong, et al.
Publicado: (2019)

Intratumoral STING activation causes durable immunogenic tumor eradication in the KP soft tissue sarcoma model
por: Marritt, Kayla L., et al.
Publicado: (2023)

High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants
por: Willeit, Peter, et al.
Publicado: (2017)

AB052. The nursing of endoscopic submucosal dissection for non-muscle invasive bladder tumor
por: Zhan, Fengli, et al.
Publicado: (2018)

Thromboinflammatory Biomarkers in COVID-19: Systematic Review and Meta-analysis of 17,052 Patients
por: Chaudhary, Rahul, et al.
Publicado: (2021)

ODP052 Recurrent Pheochromocytoma Concerning For Surgical Seeding From Prior Partial Adrenalectomy
por: Upadhyaya, Neelam, et al.
Publicado: (2022)

O052 Patient Preference and Acceptability of Sleep Diagnostic Tests during early Pregnancy
por: Clements, F, et al.
Publicado: (2023)

Tumor Immunogenic Cell Death as a Mediator of Intratumor CD8 T-Cell Recruitment
por: Roussot, Nicolas, et al.
Publicado: (2022)

Toll-Like Receptor 9 Agonists for Cancer Therapy
por: Melisi, Davide, et al.
Publicado: (2014)

Toll-Like Receptor Agonists as Adjuvants for Allergen Immunotherapy
por: Kirtland, Max E., et al.
Publicado: (2020)

Applications and clinical trial landscape using Toll-like receptor agonists to reduce the toll of cancer
por: Rolfo, Christian, et al.
Publicado: (2023)

Intratumoral immune activation with TLR4 agonist synergizes with effector T cells to eradicate established murine tumors
por: Albershardt, Tina C., et al.
Publicado: (2020)

Erectile Dysfunction in Qatar: Prevalence and Risk Factors in 1,052 Participants—A Pilot Study
por: Al Naimi, Abdulla, et al.
Publicado: (2014)

Improvement of spontaneous locomotor activity with JAK inhibition by JTE-052 in rat adjuvant-induced arthritis
por: Tanimoto, Atsuo, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_gibel3djr74kh2cotnarg5bt2v