CD8(+) T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine

The Tec kinase IL-2–inducible T cell kinase (ITK) regulates the expression of TCR-induced genes. Itk(−/−) T cell responses are impaired but not absent. ITK inhibition prevented colitis disease progression and impaired T cell migration to the colon in mice. To examine the function of ITK in T cell mi...

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Detalles Bibliográficos
Autores principales: Cho, Hyoung-Soo, Ha, Soyoung, Shin, Hyun Mu, Reboldi, Andrea, Hall, Jason A., Huh, Jun R., Usherwood, Edward J., Berg, Leslie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521019/
https://www.ncbi.nlm.nih.gov/pubmed/32034085
http://dx.doi.org/10.4049/immunohorizons.1900093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521019/
https://www.ncbi.nlm.nih.gov/pubmed/32034085
http://dx.doi.org/10.4049/immunohorizons.1900093

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