Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion

Previous research demonstrates that, in clinically relevant concentrations, azithromycin can boost the ability of RNA viruses to induce type 1 interferon by amplifying the expression and virally-mediated activation of MDA5. O-GlcNAcylation of MAVS, a down-stream target of MDA5, renders it more effec...

Descripción completa

Detalles Bibliográficos
Autores principales: DiNicolantonio, James J., Barroso-Aranda, Jorge, McCarty, Mark F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Federation of Immunological Societies. Published by Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521214/
https://www.ncbi.nlm.nih.gov/pubmed/33002511
http://dx.doi.org/10.1016/j.imlet.2020.09.008
_version_ 1783587929926402048
author DiNicolantonio, James J.
Barroso-Aranda, Jorge
McCarty, Mark F.
author_facet DiNicolantonio, James J.
Barroso-Aranda, Jorge
McCarty, Mark F.
author_sort DiNicolantonio, James J.
collection PubMed
description Previous research demonstrates that, in clinically relevant concentrations, azithromycin can boost the ability of RNA viruses to induce type 1 interferon by amplifying the expression and virally-mediated activation of MDA5. O-GlcNAcylation of MAVS, a down-stream target of MDA5, renders it more effective for type 1 interferon induction. High-dose glucosamine administration up-regulates O-GlcNAcylation by increasing the cellular pool of UDP-N-acetylglucosamine. Hence, it is proposed that joint administration of azithromycin and high-dose glucosamine, early in the course of RNA virus infections, may interact in a complementary fashion to aid their control by enhancing type 1 interferon induction
format Online
Article
Text
id pubmed-7521214
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher European Federation of Immunological Societies. Published by Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-75212142020-09-29 Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion DiNicolantonio, James J. Barroso-Aranda, Jorge McCarty, Mark F. Immunol Lett Article Previous research demonstrates that, in clinically relevant concentrations, azithromycin can boost the ability of RNA viruses to induce type 1 interferon by amplifying the expression and virally-mediated activation of MDA5. O-GlcNAcylation of MAVS, a down-stream target of MDA5, renders it more effective for type 1 interferon induction. High-dose glucosamine administration up-regulates O-GlcNAcylation by increasing the cellular pool of UDP-N-acetylglucosamine. Hence, it is proposed that joint administration of azithromycin and high-dose glucosamine, early in the course of RNA virus infections, may interact in a complementary fashion to aid their control by enhancing type 1 interferon induction European Federation of Immunological Societies. Published by Elsevier B.V. 2020-12 2020-09-28 /pmc/articles/PMC7521214/ /pubmed/33002511 http://dx.doi.org/10.1016/j.imlet.2020.09.008 Text en © 2020 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
DiNicolantonio, James J.
Barroso-Aranda, Jorge
McCarty, Mark F.
Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion
title Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion
title_full Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion
title_fullStr Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion
title_full_unstemmed Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion
title_short Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion
title_sort azithromycin and glucosamine may amplify the type 1 interferon response to rna viruses in a complementary fashion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521214/
https://www.ncbi.nlm.nih.gov/pubmed/33002511
http://dx.doi.org/10.1016/j.imlet.2020.09.008
work_keys_str_mv AT dinicolantoniojamesj azithromycinandglucosaminemayamplifythetype1interferonresponsetornavirusesinacomplementaryfashion
AT barrosoarandajorge azithromycinandglucosaminemayamplifythetype1interferonresponsetornavirusesinacomplementaryfashion
AT mccartymarkf azithromycinandglucosaminemayamplifythetype1interferonresponsetornavirusesinacomplementaryfashion

Ejemplares similares