Lysosomal dysfunction of corneal fibroblasts underlies the pathogenesis of Granular Corneal Dystrophy Type 2 and can be rescued by TFEB

Granular corneal dystrophy type 2 (GCD2) is the most common form of transforming growth factor β‐induced (TGFBI) gene‐linked corneal dystrophy and is pathologically characterized by the corneal deposition of mutant‐TGFBIp. The defective autophagic degradation of pathogenic mutant‐TGFBIp has been sho...

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Detalles Bibliográficos
Autores principales: Choi, Seung‐il, Woo, Jong Hwan, Kim, Eung Kweon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521267/
https://www.ncbi.nlm.nih.gov/pubmed/32667742
http://dx.doi.org/10.1111/jcmm.15646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521267/
https://www.ncbi.nlm.nih.gov/pubmed/32667742
http://dx.doi.org/10.1111/jcmm.15646

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