Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling

Single-cell gene expression is inherently variable, but how this variability is controlled in response to stimulation remains unclear. Here, we use single-cell RNA-seq and single-molecule mRNA counting (smFISH) to study inducible gene expression in the immune toll-like receptor system. We show that...

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Detalles Bibliográficos
Autores principales: Bagnall, James, Rowe, William, Alachkar, Nissrin, Roberts, James, England, Hazel, Clark, Christopher, Platt, Mark, Jackson, Dean A., Muldoon, Mark, Paszek, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521480/
https://www.ncbi.nlm.nih.gov/pubmed/32918862
http://dx.doi.org/10.1016/j.cels.2020.08.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521480/
https://www.ncbi.nlm.nih.gov/pubmed/32918862
http://dx.doi.org/10.1016/j.cels.2020.08.007

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