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Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling
Single-cell gene expression is inherently variable, but how this variability is controlled in response to stimulation remains unclear. Here, we use single-cell RNA-seq and single-molecule mRNA counting (smFISH) to study inducible gene expression in the immune toll-like receptor system. We show that...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521480/ https://www.ncbi.nlm.nih.gov/pubmed/32918862 http://dx.doi.org/10.1016/j.cels.2020.08.007 |