Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells

Here we demonstrated that sulforaphane-cysteine (SFN-Cys) regulated cell cycle-related protein expressions in G0/G1 and G2/M phases of U87MG cells via High Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS) and proteomics analysis. Further, mRNA products of CDK4, CDK6...

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Detalles Bibliográficos
Autores principales: Li, Juntao, Zhou, Yan, Yan, Yuting, Zheng, Zhongnan, Hu, Yabin, Wu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521484/
https://www.ncbi.nlm.nih.gov/pubmed/32860670
http://dx.doi.org/10.18632/aging.103537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521484/
https://www.ncbi.nlm.nih.gov/pubmed/32860670
http://dx.doi.org/10.18632/aging.103537

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