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Parietal epithelial cell differentiation to a podocyte fate in the aged mouse kidney

Healthy aging is typified by a progressive and absolute loss of podocytes over the lifespan of animals and humans. To test the hypothesis that a subset of glomerular parietal epithelial cell (PEC) progenitors transition to a podocyte fate with aging, dual reporter PEC-rtTA|LC1|tdTomato|Nphs1-FLPo|FR...

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Detalles Bibliográficos
Autores principales: Kaverina, Natalya V., Eng, Diana G., Miner, Jeffrey H., Pippin, Jeffrey W., Shankland, Stuart J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521511/
https://www.ncbi.nlm.nih.gov/pubmed/32858527
http://dx.doi.org/10.18632/aging.103788