Shikonin overcomes drug resistance and induces necroptosis by regulating the miR-92a-1-5p/MLKL axis in chronic myeloid leukemia

Development of resistance to tyrosine kinase inhibitors (TKIs) targeting the BCR/ABL fusion protein represents a major challenge in the treatment of chronic myeloid leukemia (CML). Since apoptosis resistance is the fundamental mechanism impeding TKIs’ therapeutic effects, alternative approaches that...

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Detalles Bibliográficos
Autores principales: Huang, Xianbo, Chen, Zhenzhen, Ni, Fan, Ye, Xiujin, Qian, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521527/
https://www.ncbi.nlm.nih.gov/pubmed/32927433
http://dx.doi.org/10.18632/aging.103844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521527/
https://www.ncbi.nlm.nih.gov/pubmed/32927433
http://dx.doi.org/10.18632/aging.103844

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