Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis

Deconvolution of syphilis pathogenesis and selection of candidate syphilis vaccinogens requires detailed knowledge of the molecular architecture of the Treponema pallidum outer membrane (OM). The T. pallidum OM contains a low density of integral OM proteins, while the spirochete’s many lipoprotein i...

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Detalles Bibliográficos
Autores principales: Luthra, Amit, Montezuma-Rusca, Jairo M., La Vake, Carson J., LeDoyt, Morgan, Delgado, Kristina N., Davenport, Timothy C., Fiel-Gan, Mary, Caimano, Melissa J., Radolf, Justin D., Hawley, Kelly L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521688/
https://www.ncbi.nlm.nih.gov/pubmed/32936831
http://dx.doi.org/10.1371/journal.ppat.1008871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521688/
https://www.ncbi.nlm.nih.gov/pubmed/32936831
http://dx.doi.org/10.1371/journal.ppat.1008871

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