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Discovering functional sequences with RELICS, an analysis method for CRISPR screens
CRISPR screens are a powerful technology for the identification of genome sequences that affect cellular phenotypes such as gene expression, survival, and proliferation. By targeting non-coding sequences for perturbation, CRISPR screens have the potential to systematically discover novel functional...
Autores principales: | Fiaux, Patrick C., Chen, Hsiuyi V., Chen, Poshen B., Chen, Aaron R., McVicker, Graham |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521704/ https://www.ncbi.nlm.nih.gov/pubmed/32936799 http://dx.doi.org/10.1371/journal.pcbi.1008194 |
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