Whole-exome sequencing of 79 xenografts as a potential approach for the identification of genetic variants associated with sensitivity to cytotoxic anticancer drugs

Chemotherapy response remains unpredictable in most patients with cancer. In this study, we performed whole-exome sequencing of 79 cancer xenografts derived from human cancer tissues to identify genetic predictors of chemosensitivity to nine cytotoxic anticancer drugs. Xenografts were harvested from...

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Detalles Bibliográficos
Autores principales: Udagawa, Chihiro, Sasaki, Yasushi, Tanizawa, Yasuhiro, Suemizu, Hiroshi, Ohnishi, Yasuyuki, Nakamura, Yasukazu, Tokino, Takashi, Zembutsu, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521756/
https://www.ncbi.nlm.nih.gov/pubmed/32986753
http://dx.doi.org/10.1371/journal.pone.0239614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521756/
https://www.ncbi.nlm.nih.gov/pubmed/32986753
http://dx.doi.org/10.1371/journal.pone.0239614

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