Wnt signaling mediates oncogenic synergy between Akt and Dlx5 in T-cell lymphomagenesis by enhancing cholesterol synthesis

The Dlx5 homeobox gene was first implicated as an oncogene in a T-ALL mouse model expressing myristoylated (Myr) Akt2. Furthermore, overexpression of Dlx5 was sufficient to drive T-ALL in mice by directly activating Akt and Notch signaling. These findings implied that Akt2 cooperates with Dlx5 in T-...

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Detalles Bibliográficos
Autores principales: Tan, Yinfei, Sementino, Eleonora, Liu, Zemin, Cai, Kathy Q., Testa, Joseph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522078/
https://www.ncbi.nlm.nih.gov/pubmed/32985581
http://dx.doi.org/10.1038/s41598-020-72822-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522078/
https://www.ncbi.nlm.nih.gov/pubmed/32985581
http://dx.doi.org/10.1038/s41598-020-72822-w

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