Insight into an Oxidative DNA-Cleaving DNAzyme: Multiple Cofactors, the Catalytic Core Map and a Highly Efficient Variant

An oxidative DNA-cleaving DNAzyme (PL) employs a double-cofactor model “X/Cu(2+)” for catalysis. Herein, we verified that reduced nicotinamide adenine dinucleotide (NADH), flavin mononucleotide, cysteine, dithiothreitol, catechol, resorcinol, hydroquinone, phloroglucinol, o-phenylenediamine, 3,3′,5,...

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Detalles Bibliográficos
Autores principales: Yu, Wenqian, Wang, Shijin, Cao, Dongling, Rui, Hongyue, Liu, Chengcheng, Sheng, Yongjie, Sun, Yanhong, Zhang, Jin, Xu, Jiacui, Jiang, Dazhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522124/
https://www.ncbi.nlm.nih.gov/pubmed/33083724
http://dx.doi.org/10.1016/j.isci.2020.101555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522124/
https://www.ncbi.nlm.nih.gov/pubmed/33083724
http://dx.doi.org/10.1016/j.isci.2020.101555

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