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Resveratrol stereoselectively affected (±)warfarin pharmacokinetics and enhanced the anticoagulation effect
Resveratrol (RVT) has various beneficial bioactivities and popularly used as a dietary supplement. RVT showed inhibitions on CYP1A2/2C9/3A4, breast cancer resistance protein (BCRP), and some conjugated metabolites of RVT also inhibited BCRP. (±)Warfarin, an anticoagulant for cardiovascular disease b...
Autores principales: | Huang, Tse-Yin, Yu, Chung-Ping, Hsieh, Yow-Wen, Lin, Shiuan-Pey, Hou, Yu-Chi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522226/ https://www.ncbi.nlm.nih.gov/pubmed/32985569 http://dx.doi.org/10.1038/s41598-020-72694-0 |
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