Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair

DNA damage sensors DDB2 and XPC initiate global genome nucleotide excision repair (NER) to protect DNA from mutagenesis caused by helix-distorting lesions. XPC recognizes helical distortions by binding to unpaired ssDNA opposite DNA lesions. DDB2 binds to UV-induced lesions directly and facilitates...

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Detalles Bibliográficos
Autores principales: Ribeiro-Silva, Cristina, Sabatella, Mariangela, Helfricht, Angela, Marteijn, Jurgen A., Theil, Arjan F., Vermeulen, Wim, Lans, Hannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522231/
https://www.ncbi.nlm.nih.gov/pubmed/32985517
http://dx.doi.org/10.1038/s41467-020-18705-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522231/
https://www.ncbi.nlm.nih.gov/pubmed/32985517
http://dx.doi.org/10.1038/s41467-020-18705-0

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