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Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair
DNA damage sensors DDB2 and XPC initiate global genome nucleotide excision repair (NER) to protect DNA from mutagenesis caused by helix-distorting lesions. XPC recognizes helical distortions by binding to unpaired ssDNA opposite DNA lesions. DDB2 binds to UV-induced lesions directly and facilitates...
Autores principales: | Ribeiro-Silva, Cristina, Sabatella, Mariangela, Helfricht, Angela, Marteijn, Jurgen A., Theil, Arjan F., Vermeulen, Wim, Lans, Hannes |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522231/ https://www.ncbi.nlm.nih.gov/pubmed/32985517 http://dx.doi.org/10.1038/s41467-020-18705-0 |
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