Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN

Somatic mutations in the calreticulin (CALR) gene are associated with approximately 30% of essential thrombocythemia (ET) and primary myelofibrosis (PMF). CALR mutations, including the two most frequent 52 bp deletion (del52) and 5 bp insertion (ins5), induce a frameshift to the same alternative rea...

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Detalles Bibliográficos
Autores principales: Benlabiod, Camélia, Cacemiro, Maira da Costa, Nédélec, Audrey, Edmond, Valérie, Muller, Delphine, Rameau, Philippe, Touchard, Laure, Gonin, Patrick, Constantinescu, Stefan N., Raslova, Hana, Villeval, Jean-Luc, Vainchenker, William, Plo, Isabelle, Marty, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522233/
https://www.ncbi.nlm.nih.gov/pubmed/32985500
http://dx.doi.org/10.1038/s41467-020-18691-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522233/
https://www.ncbi.nlm.nih.gov/pubmed/32985500
http://dx.doi.org/10.1038/s41467-020-18691-3

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