A Novel Proteomic Method Reveals NLS Tagging of T-DM1 Contravenes Classical Nuclear Transport in a Model of HER2-Positive Breast Cancer

The next breakthrough for protein therapeutics is effective intracellular delivery and accumulation within target cells. Nuclear localization signal (NLS)-tagged therapeutics have been hindered by the lack of efficient nuclear localization due to endosome entrapment. Although development of strategi...

Descripción completa

Detalles Bibliográficos
Autores principales: Lacasse, Vincent, Beaudoin, Simon, Jean, Steve, Leyton, Jeffrey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522293/
https://www.ncbi.nlm.nih.gov/pubmed/33024794
http://dx.doi.org/10.1016/j.omtm.2020.08.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522293/
https://www.ncbi.nlm.nih.gov/pubmed/33024794
http://dx.doi.org/10.1016/j.omtm.2020.08.016

Ejemplares similares