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Identification of P-Rex1 in the Regulation of Liver Cancer Cell Proliferation and Migration via HGF/c-Met/Akt Pathway

BACKGROUND: Rho-GTPases and their activators, guanine nucleotide exchange factors (GEFs), are increasingly being recognized as essential mediators of oncogenic signaling. Although it is known that P-Rex1, a member of the Dbl family of GEFs for the Rac small GTPase, contributes to the migration of ca...

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Detalles Bibliográficos
Autores principales: Qiu, Wancheng, Chang, Yanhua, Liu, Jing, Yang, Xu, Yu, Yan, Li, Jiajia, Liang, Qing, Sun, Guangchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522411/
https://www.ncbi.nlm.nih.gov/pubmed/33061433
http://dx.doi.org/10.2147/OTT.S265592