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Global quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by an early, asymptomatic phase (AsymAD) in which individuals exhibit amyloid-beta (Aβ) plaque accumulation in the absence of clinically detectable cognitive decline. Here we report an unbiased multiplex quantitative proteomic and phosphoproteomic analysis u...

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Detalles Bibliográficos
Autores principales: Ping, Lingyan, Kundinger, Sean R., Duong, Duc M., Yin, Luming, Gearing, Marla, Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522715/
https://www.ncbi.nlm.nih.gov/pubmed/32985496
http://dx.doi.org/10.1038/s41597-020-00650-8