Type 2 Innate Lymphoid Cells Induce CNS Demyelination in an HSV-IL-2 Mouse Model of Multiple Sclerosis

We previously reported that infection of different mouse strains with a recombinant HSV-1 expressing IL-2 (HSV-IL-2) caused CNS demyelination. Histologic examination of infected IL-2rα(−/−), IL-2rβ(−/−), and IL-2rγ(−/−) mice showed demyelination in the CNS of IL-2rα(−/−) and IL-2rβ(−/−) mice but not...

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Detalles Bibliográficos
Autores principales: Hirose, Satoshi, Jahani, Pedram Shafiei, Wang, Shaohui, Jaggi, Ujjaldeep, Tormanen, Kati, Yu, Jack, Kato, Mihoko, Akbari, Omid, Ghiasi, Homayon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522755/
https://www.ncbi.nlm.nih.gov/pubmed/33083718
http://dx.doi.org/10.1016/j.isci.2020.101549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522755/
https://www.ncbi.nlm.nih.gov/pubmed/33083718
http://dx.doi.org/10.1016/j.isci.2020.101549

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