Circadian Dysregulation of the TGFβ/SMAD4 Pathway Modulates Metastatic Properties and Cell Fate Decisions in Pancreatic Cancer Cells

Impairment of circadian rhythms impacts carcinogenesis. SMAD4, a clock-controlled gene and central component of the TGFβ canonical pathway, is frequently mutated in pancreatic ductal adenocarcinoma (PDA), leading to decreased survival. Here, we used an in vitro PDA model of SMAD4-positive and SMAD4-...

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Detalles Bibliográficos
Autores principales: Li, Yin, Basti, Alireza, Yalçin, Müge, Relógio, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522758/
https://www.ncbi.nlm.nih.gov/pubmed/33083720
http://dx.doi.org/10.1016/j.isci.2020.101551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522758/
https://www.ncbi.nlm.nih.gov/pubmed/33083720
http://dx.doi.org/10.1016/j.isci.2020.101551

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