Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling

ABSTRACT: BACKGROUND: Rewiring of metabolism induced by oncogenic K-Ras in cancer cells involves both glucose and glutamine utilization sustaining enhanced, unrestricted growth. The development of effective anti-cancer treatments targeting metabolism may be facilitated by the identification and rati...

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Detalles Bibliográficos
Autores principales: Gaglio, Daniela, Bonanomi, Marcella, Valtorta, Silvia, Bharat, Rohit, Ripamonti, Marilena, Conte, Federica, Fiscon, Giulia, Righi, Nicole, Napodano, Elisabetta, Papa, Federico, Raccagni, Isabella, Parker, Seth J., Cifola, Ingrid, Camboni, Tania, Paci, Paola, Colangelo, Anna Maria, Vanoni, Marco, Metallo, Christian M., Moresco, Rosa Maria, Alberghina, Lilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523077/
https://www.ncbi.nlm.nih.gov/pubmed/33005401
http://dx.doi.org/10.1186/s40170-020-00227-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523077/
https://www.ncbi.nlm.nih.gov/pubmed/33005401
http://dx.doi.org/10.1186/s40170-020-00227-4

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