Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

Effective therapeutics aimed at mitigating COVID-19 symptoms are urgently needed. SARS-CoV-2 induced hypercytokinemia and systemic inflammation are associated with disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor with potent anti-inflammatory properties is currently being invest...

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Detalles Bibliográficos
Autores principales: Hoang, Timothy N., Pino, Maria, Boddapati, Arun K., Viox, Elise G., Starke, Carly E., Upadhyay, Amit A., Gumber, Sanjeev, Busman-Sahay, Kathleen, Strongin, Zachary, Harper, Justin L., Tharp, Gregory K., Pellegrini, Kathryn L., Kirejczyk, Shannon, Zandi, Keivan, Tao, Sijia, Horton, Tristan R., Beagle, Elizabeth N., Mahar, Ernestine A., Lee, Michelle YH, Cohen, Joyce, Jean, Sherrie M., Wood, Jennifer S., Connor-Stroud, Fawn, Stammen, Rachelle L., Delmas, Olivia M., Wang, Shelly, Cooney, Kimberly A., Sayegh, Michael N., Wang, Lanfang, Weiskopf, Daniela, Filev, Peter D., Waggoner, Jesse, Piantadosi, Anne, Kasturi, Sudhir P., Al-Shakhshir, Hilmi, Ribeiro, Susan P., Sekaly, Rafick P., Levit, Rebecca D., Estes, Jacob D., Vanderford, Thomas H., Schinazi, Raymond F., Bosinger, Steven E., Paiardini, Mirko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523106/
https://www.ncbi.nlm.nih.gov/pubmed/32995780
http://dx.doi.org/10.1101/2020.09.16.300277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523106/
https://www.ncbi.nlm.nih.gov/pubmed/32995780
http://dx.doi.org/10.1101/2020.09.16.300277

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