Introduction of two prolines and removal of the polybasic cleavage site leads to optimal efficacy of a recombinant spike based SARS-CoV-2 vaccine in the mouse model

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the prime target for vaccine development. The spike protein mediates both binding to host cells and membrane fusion and is also so far the only known viral target of neutralizing antibodies. Coro...

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Detalles Bibliográficos
Autores principales: Amanat, Fatima, Strohmeier, Shirin, Rathnasinghe, Raveen, Schotsaert, Michael, Coughlan, Lynda, García-Sastre, Adolfo, Krammer, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523111/
https://www.ncbi.nlm.nih.gov/pubmed/32995785
http://dx.doi.org/10.1101/2020.09.16.300970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523111/
https://www.ncbi.nlm.nih.gov/pubmed/32995785
http://dx.doi.org/10.1101/2020.09.16.300970

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