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Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein
Understanding how human ACE2 genetic variants differ in their recognition by SARS-CoV-2 can have a major impact in leveraging ACE2 as an axis for treating and preventing COVID-19. In this work, we experimentally interrogate thousands of ACE2 mutants to identify over one hundred human single-nucleoti...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523126/ https://www.ncbi.nlm.nih.gov/pubmed/32995796 http://dx.doi.org/10.1101/2020.09.17.301861 |