Discovery of human ACE2 variants with altered recognition by the SARS-CoV-2 spike protein

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Understanding how human ACE2 genetic variants differ in their recognition by SARS-CoV-2 can have a major impact in leveraging ACE2 as an axis for treating and preventing COVID-19. In this work, we experimentally interrogate thousands of ACE2 mutants to identify over one hundred human single-nucleoti...

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Detalles Bibliográficos
Autores principales: Heinzelman, Pete, Romero, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523126/
https://www.ncbi.nlm.nih.gov/pubmed/32995796
http://dx.doi.org/10.1101/2020.09.17.301861

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