Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma

BACKGROUND: Glioblastoma (GBM) has been extensively researched over the last few decades, yet despite aggressive multimodal treatment, recurrence is inevitable and second-line treatment options are limited. Here, we demonstrate how high-throughput screening (HTS) in multicellular spheroids can gener...

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Detalles Bibliográficos
Autores principales: Taylor, Jessica T, Ellison, Stuart, Pandele, Alina, Wood, Shaun, Nathan, Erica, Forte, Gabriella, Parker, Helen, Zindy, Egor, Elvin, Mark, Dickson, Alan, Williams, Kaye J, Karabatsou, Konstantina, McCabe, Martin, McBain, Catherine, Bigger, Brian W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523458/
https://www.ncbi.nlm.nih.gov/pubmed/32227096
http://dx.doi.org/10.1093/neuonc/noaa051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523458/
https://www.ncbi.nlm.nih.gov/pubmed/32227096
http://dx.doi.org/10.1093/neuonc/noaa051

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