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Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication

The processes that control where higher eukaryotic cells initiate DNA replication throughout the genome are not understood clearly. In metazoans, the Treslin-MTBP complex mediates critical final steps in formation of the activated replicative helicase prior to initiation of replication. Here, we map...

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Detalles Bibliográficos
Autores principales: Kumagai, Akiko, Dunphy, William G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523632/
https://www.ncbi.nlm.nih.gov/pubmed/32966791
http://dx.doi.org/10.1016/j.celrep.2020.108178