A cell-based high-content screen identifies isocotoin as a small molecule inhibitor of the meiosis-specific MEIOB–SPATA22 complex(†)

MEIOB and SPATA22 are meiosis-specific proteins, interact with each other, and are essential for meiotic recombination and fertility. Aspartic acid 383 (D383) in MEIOB is critical for its interaction with SPATA22 in biochemical studies. Here we report that genetic studies validate the requirement of...

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Detalles Bibliográficos
Autores principales: Xu, Yang, Liu, Rong, Leu, N Adrian, Zhang, Lei, Ibragmova, Ilsiya, Schultz, David C, Wang, P Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Contraceptive Special Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523692/
https://www.ncbi.nlm.nih.gov/pubmed/32463099
http://dx.doi.org/10.1093/biolre/ioaa062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523692/
https://www.ncbi.nlm.nih.gov/pubmed/32463099
http://dx.doi.org/10.1093/biolre/ioaa062

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