Cargando…

Refining surgical models of osteoarthritis in mice and rats alters pain phenotype but not joint pathology

The relationship between osteoarthritis (OA) structural change and pain is complex. Surgical models of OA in rodents are often rapid in onset, limiting mechanistic utility and translational validity. We aimed to investigate the effect of refining surgical small rodent models of OA on both joint path...

Descripción completa

Detalles Bibliográficos
Autores principales: Gowler, Peter R. W., Mapp, Paul I., Burston, James J., Shahtaheri, Mohsen, Walsh, David A., Chapman, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523978/
https://www.ncbi.nlm.nih.gov/pubmed/32991618
http://dx.doi.org/10.1371/journal.pone.0239663