Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production

We hypothesized that the antimicrobial peptide cathelicidin has a physiological role in regulating gut inflammatory homeostasis. We determined that cathelicidin synergizes with LPS to facilitate its internalization and signaling via endosomic TLR4 in colonic epithelium, evoking synthesis of the huma...

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Detalles Bibliográficos
Autores principales: Holani, Ravi, Babbar, Anshu, Blyth, Graham A. D., Lopes, Fernando, Jijon, Humberto, McKay, Derek M., Hollenberg, Morley D., Cobo, Eduardo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524372/
https://www.ncbi.nlm.nih.gov/pubmed/32658599
http://dx.doi.org/10.1080/19490976.2020.1785802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524372/
https://www.ncbi.nlm.nih.gov/pubmed/32658599
http://dx.doi.org/10.1080/19490976.2020.1785802

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