Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches

Heat shock protein 90 (Hsp90) is a molecular chaperone that plays an important role in tumour biology by promoting the stabilisation and activity of oncogenic ‘client’ proteins. Inhibition of Hsp90 by small-molecule drugs, acting via its ATP hydrolysis site, has shown promise as a molecularly target...

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Detalles Bibliográficos
Autores principales: Darby, John F., Vidler, Lewis R., Simpson, Peter J., Al-Lazikani, Bissan, Matthews, Stephen J., Sharp, Swee Y., Pearl, Laurence H., Hoelder, Swen, Workman, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524759/
https://www.ncbi.nlm.nih.gov/pubmed/32994435
http://dx.doi.org/10.1038/s41598-020-71969-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524759/
https://www.ncbi.nlm.nih.gov/pubmed/32994435
http://dx.doi.org/10.1038/s41598-020-71969-w

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