Mutual Antagonism of Hypoxia-Inducible Factor Isoforms in Cardiac, Vascular, and Renal Disorders

Hypoxia-inducible factor (HIF)-1α and HIF-2α promote cellular adaptation to acute hypoxia, but during prolonged activation, these isoforms exert mutually antagonistic effects on the redox state and on proinflammatory pathways. Sustained HIF-1α signaling can increase oxidative stress, inflammation, a...

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Detalles Bibliográficos
Autor principal: Packer, Milton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
State-of-the-Art Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524787/
https://www.ncbi.nlm.nih.gov/pubmed/33015417
http://dx.doi.org/10.1016/j.jacbts.2020.05.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524787/
https://www.ncbi.nlm.nih.gov/pubmed/33015417
http://dx.doi.org/10.1016/j.jacbts.2020.05.006

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