Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition

Fibrotic remodeling of the heart in response to injury contributes to heart failure, yet therapies to treat fibrosis remain elusive. Yes-associated protein (YAP) is activated in cardiac fibroblasts by myocardial infarction, and genetic inhibition of fibroblast YAP attenuates myocardial infarction–in...

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Detalles Bibliográficos
Autores principales: Francisco, Jamie, Zhang, Yu, Jeong, Jae Im, Mizushima, Wataru, Ikeda, Shohei, Ivessa, Andreas, Oka, Shinichi, Zhai, Peiyong, Tallquist, Michelle D., Del Re, Dominic P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524792/
https://www.ncbi.nlm.nih.gov/pubmed/33015415
http://dx.doi.org/10.1016/j.jacbts.2020.07.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524792/
https://www.ncbi.nlm.nih.gov/pubmed/33015415
http://dx.doi.org/10.1016/j.jacbts.2020.07.009

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