Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition

Fibrotic remodeling of the heart in response to injury contributes to heart failure, yet therapies to treat fibrosis remain elusive. Yes-associated protein (YAP) is activated in cardiac fibroblasts by myocardial infarction, and genetic inhibition of fibroblast YAP attenuates myocardial infarction–in...

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Autores principales: Francisco, Jamie, Zhang, Yu, Jeong, Jae Im, Mizushima, Wataru, Ikeda, Shohei, Ivessa, Andreas, Oka, Shinichi, Zhai, Peiyong, Tallquist, Michelle D., Del Re, Dominic P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524792/
https://www.ncbi.nlm.nih.gov/pubmed/33015415
http://dx.doi.org/10.1016/j.jacbts.2020.07.009
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author Francisco, Jamie
Zhang, Yu
Jeong, Jae Im
Mizushima, Wataru
Ikeda, Shohei
Ivessa, Andreas
Oka, Shinichi
Zhai, Peiyong
Tallquist, Michelle D.
Del Re, Dominic P.
author_facet Francisco, Jamie
Zhang, Yu
Jeong, Jae Im
Mizushima, Wataru
Ikeda, Shohei
Ivessa, Andreas
Oka, Shinichi
Zhai, Peiyong
Tallquist, Michelle D.
Del Re, Dominic P.
author_sort Francisco, Jamie
collection PubMed
description Fibrotic remodeling of the heart in response to injury contributes to heart failure, yet therapies to treat fibrosis remain elusive. Yes-associated protein (YAP) is activated in cardiac fibroblasts by myocardial infarction, and genetic inhibition of fibroblast YAP attenuates myocardial infarction–induced cardiac dysfunction and fibrosis. YAP promotes myofibroblast differentiation and associated extracellular matrix gene expression through engagement of TEA domain transcription factor 1 and subsequent de novo expression of myocardin-related transcription factor A. Thus, fibroblast YAP is a promising therapeutic target to prevent fibrotic remodeling and heart failure.
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spelling pubmed-75247922020-10-02 Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition Francisco, Jamie Zhang, Yu Jeong, Jae Im Mizushima, Wataru Ikeda, Shohei Ivessa, Andreas Oka, Shinichi Zhai, Peiyong Tallquist, Michelle D. Del Re, Dominic P. JACC Basic Transl Sci Preclinical Research Fibrotic remodeling of the heart in response to injury contributes to heart failure, yet therapies to treat fibrosis remain elusive. Yes-associated protein (YAP) is activated in cardiac fibroblasts by myocardial infarction, and genetic inhibition of fibroblast YAP attenuates myocardial infarction–induced cardiac dysfunction and fibrosis. YAP promotes myofibroblast differentiation and associated extracellular matrix gene expression through engagement of TEA domain transcription factor 1 and subsequent de novo expression of myocardin-related transcription factor A. Thus, fibroblast YAP is a promising therapeutic target to prevent fibrotic remodeling and heart failure. Elsevier 2020-09-28 /pmc/articles/PMC7524792/ /pubmed/33015415 http://dx.doi.org/10.1016/j.jacbts.2020.07.009 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preclinical Research
Francisco, Jamie
Zhang, Yu
Jeong, Jae Im
Mizushima, Wataru
Ikeda, Shohei
Ivessa, Andreas
Oka, Shinichi
Zhai, Peiyong
Tallquist, Michelle D.
Del Re, Dominic P.
Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition
title Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition
title_full Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition
title_fullStr Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition
title_full_unstemmed Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition
title_short Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition
title_sort blockade of fibroblast yap attenuates cardiac fibrosis and dysfunction through mrtf-a inhibition
topic Preclinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524792/
https://www.ncbi.nlm.nih.gov/pubmed/33015415
http://dx.doi.org/10.1016/j.jacbts.2020.07.009
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