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Cancer-associated fibroblasts mediate cancer progression and remodel the tumouroid stroma

BACKGROUND: Cancer-associated fibroblasts (CAFs) are highly differentiated and heterogeneous cancer-stromal cells that promote tumour growth, angiogenesis and matrix remodelling. METHODS: We utilised an adapted version of a previously developed 3D in vitro model of colorectal cancer, composed of a c...

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Detalles Bibliográficos
Autores principales: Pape, Judith, Magdeldin, Tarig, Stamati, Katerina, Nyga, Agata, Loizidou, Marilena, Emberton, Mark, Cheema, Umber
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524802/
https://www.ncbi.nlm.nih.gov/pubmed/32641866
http://dx.doi.org/10.1038/s41416-020-0973-9