Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells

Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are postulated to favor a pathological pulmonary endothelial cell (EC) phenotype in pulmonary arterial hypertension (PAH). BMP9 is shown to reinstate BMP receptor type-II (BMPR2) levels and thereby mitig...

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Detalles Bibliográficos
Autores principales: Szulcek, Robert, Sanchez-Duffhues, Gonzalo, Rol, Nina, Pan, Xiaoke, Tsonaka, Roula, Dickhoff, Chris, Yung, Lai Ming, Manz, Xue D., Kurakula, Kondababu, Kiełbasa, Szymon M., Mei, Hailiang, Timens, Wim, Yu, Paul B., Bogaard, Harm-Jan, Goumans, Marie-José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524846/
https://www.ncbi.nlm.nih.gov/pubmed/32813135
http://dx.doi.org/10.1007/s10456-020-09741-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524846/
https://www.ncbi.nlm.nih.gov/pubmed/32813135
http://dx.doi.org/10.1007/s10456-020-09741-x

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