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Harnessing endogenous repair mechanisms for targeted gene knock-in of bovine embryos
Introducing useful traits into livestock breeding programs through gene knock-ins has proven challenging. Typically, targeted insertions have been performed in cell lines, followed by somatic cell nuclear transfer cloning, which can be inefficient. An alternative is to introduce genome editing reage...
Autores principales: | Owen, Joseph R., Hennig, Sadie L., McNabb, Bret R., Lin, Jason C., Young, Amy E., Murray, James D., Ross, Pablo J., Van Eenennaam, Alison L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525238/ https://www.ncbi.nlm.nih.gov/pubmed/32994506 http://dx.doi.org/10.1038/s41598-020-72902-x |
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