Functional Characterization of PALB2 Variants of Uncertain Significance: Toward Cancer Risk and Therapy Response Prediction

In recent years it has become clear that pathogenic variants in PALB2 are associated with a high risk for breast, ovarian and pancreatic cancer. However, the clinical relevance of variants of uncertain significance (VUS) in PALB2, which are increasingly identified through clinical genetic testing, i...

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Detalles Bibliográficos
Autores principales: Boonen, Rick A. C. M., Vreeswijk, Maaike P. G., van Attikum, Haico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525363/
https://www.ncbi.nlm.nih.gov/pubmed/33195396
http://dx.doi.org/10.3389/fmolb.2020.00169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525363/
https://www.ncbi.nlm.nih.gov/pubmed/33195396
http://dx.doi.org/10.3389/fmolb.2020.00169

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